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Clinique is a cosmetics line founded by the Estee Lauder company in 1968. Inspired by a Vogue magazine article in which a dermatologist discussed the importance of skincare, Evelyn Lauder shared the article with her mother-in-law, Estee. Also, she reached out to the beauty editor and dermatologist who participated in the article. The Clinique line was developed with their input and debuted in August 1968 at Saks Fifth Avenue.

Clinique additionally markets cosmetics and fragrances as a part of its line. The first Clinique perfume, Aromatics Elixir, was introduced in 1971. This distinct fragrance that celebrated its 40th anniversary has been a signature scent for multiple generations of ladies.

Despite the enduring popularity of Aromatics Elixir, the company's best-selling fragrance is Happy, introduced in 1997. This zesty citrus-floral scent bounced into the national consciousness through a series of lively television ads featuring the Judy Garland song, "Come On Get Happy," which was said to have inspired its name. The name, the advertising, and, therefore, the fragrance affected a chord with American ladies of the late twentieth century. Bottles flew off the shelves as the fragrance's popularity soared, and Happy would eventually spawn a men's edition and a series of flankers.

The company's products were the first cosmetics line to be allergy-tested and dermatologist-driven. Today, the products are 100% fragrance-free. All products in the line undergo extensive testing and are held to rigorous standards regarding allergic reactions. The name "Clinique" is French for "clinical," and the clinical and dermatological image of the brand is further enhanced by the trademarked white lab coats worn by its sales associates. Clinique's approach is based on the cleanliness and hygiene of the skin, and its 3-step skincare systems for various skin types are one of its most notable products.